The "DOM" is not a disk, it is a flash card in another form factor. We didn't differ between them when constructing microITX routers and telephony systems back 20 years ago, running Linux.
Once you minimize the number of writes (/var and /tmp are memdrives, periodically synced to the CF partitions) it can have a long life.
The issue here is Windows which are horrible in their structure and their patterns of working. It is not possible to do.
But the main factor is uptime at that worst case. I have Windows on the CF cards for my retro comp(s) because the comps are occasionally powered on. In this case, a Sandisk/Transcend card and any OS will work "fine". If it fails, you had the benefit of easier imaging e.g. backups with CF so it should be less of a problem. If it fails, it is not a primary hdd of your main computer that died suddenly, but a storage device for ancient PC...
I used to run FreeBSD from the thumbdrive in an almost 'read only' mode, had a fileserver in a 1U case with Intel Atom board and 2 WD Greens. It ran for few years before being blown up by power surge, there was no issue that OS is on USB, in this context.
Once you minimize the number of writes (/var and /tmp are memdrives, periodically synced to the CF partitions) it can have a long life.
The issue here is Windows which are horrible in their structure and their patterns of working. It is not possible to do.
But the main factor is uptime at that worst case. I have Windows on the CF cards for my retro comp(s) because the comps are occasionally powered on. In this case, a Sandisk/Transcend card and any OS will work "fine". If it fails, you had the benefit of easier imaging e.g. backups with CF so it should be less of a problem. If it fails, it is not a primary hdd of your main computer that died suddenly, but a storage device for ancient PC...
I used to run FreeBSD from the thumbdrive in an almost 'read only' mode, had a fileserver in a 1U case with Intel Atom board and 2 WD Greens. It ran for few years before being blown up by power surge, there was no issue that OS is on USB, in this context.