As an interesting aside:
In early Neuroscience and Brain studies, to find out what part of the Human Brain did what, people who had lesions in parts of the Brain (from strokes, trauma, tumors etc) were studied. From that a rough map was created of Brain anatomy vs Brain function. Also, lesions were deliberately inflicted on experimental subjects, to find out what part of the Brain was performing specific functions.
This went on for many years until somebody realized the defective logic in it and remarked:
If an Alien came to Earth and started a study on the Internal Combustion Engine, knowing nothing about it in advance, they might wonder what a Piston was for. As an experiment, they would remove one from the Engine, creating a lesion in the Engine if you like. The Engine would then vibrate, and they would write in their report: "The purpose of the Piston is to stop the Engine vibrating".
It was realized that if a complex system is altered from its natural working state, all sorts of unexpected effects can occur, that can lead to false conclusions. So it is better, in the case of the computer, where possible, to leave the system in its original state, (not removing IC's for example) and fault find it with tools that create the most minimal electrical disturbance during testing (like x 10 probes).