The box is physically shorter. It only fits one Omnibus backplane. The 8/e fits two. If i recall correctly one backplane is 20 slots. A basic PDP-8/e or 8/m would have 1 slot taken for the front panel, 4 slots for the basic CPU, 3 slots for each board of core memory (either 4kW or 8kW). You probably want a serial interface, that is 1 slot, you also need a 1 slot RFI shield between memory and other cards. So that is 10 slots for a very basic system. Extended memory requires "Extended Memory and Time Share Control" which is one slot. You might want "Extended arithmetic element" which is 2 slots. This leave you with 7 slots for more memory and peripherals. If you satisfy with an RX floppy controller you could put two extra sets of memory in there, for a maximum of 24kW. Not at all a bad machine. But if you want an RK05 controller and full 32kW of memory, you need another backplane.
(I'm no expert in configuring the PDP-8, I might very well have missed details. This was just to give a hint of what available/needed)